Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.56 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | KCNJ6 | P48051 | 5/20 | 0.52 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.52 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.52 |
| ▸ | CDK8 | P49336 | 4/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051125 | 0.92 | MAPK14 (0.58) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3292888 | 0.88 | MAPK14 (0.74) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL16317150 | 0.88 | NTRK1 (0.53) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4048212 | 0.82 | MAPK14 (0.62) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4051787 | 0.81 | NTRK1 (0.73) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4303810 | 0.81 | NTRK1 (0.60) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4294709 | 0.81 | MAPK14 (0.62) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3293873 | 0.80 | MAPK14 (0.74) | NTRK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3295723 | 0.80 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL16317165 | 0.80 | MAPK14 (0.56) | NTRK1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312349-A1 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS, LLC | 2009-12-17 | — | — | US | disclosed |
| US-20090312349-A1 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS, LLC | 2009-12-17 | — | — | US | disclosed |
| US-20070191336-A1 | p38 kinase inhibitors | DECIPHERA PHARMACEUTICALS, LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070191336-A1 | p38 kinase inhibitors | DECIPHERA PHARMACEUTICALS, LLC | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312349-A1 | ANTI-INFLAMMATORY MEDICAMENTS | ABL2, ABL1, PTK2 | NTRK1 399/4885MAPK14 80/4885MAPK13 183/4885 |
| US-20070191336-A1 | p38 kinase inhibitors | MAPK1, MAP3K8, MAP3K1 | NTRK1 892/4885MAPK14 29/4885MAPK13 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.