Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1557882 | 0.79 | HSD17B3 (0.37) | MEN1KMT2A | |
| SCHEMBL6204851 | 0.78 | MAPK1 (0.52) | BCHEMAPK1NAMPTMEN1KMT2A | |
| SCHEMBL6204853 | 0.73 | MAPK1 (0.48) | BCHEMAPK1NAMPTMEN1KMT2A | |
| SCHEMBL5183098 | 0.72 | MAPK1 (0.64) | MAPK1NAMPTGPR119ESR2HDAC1 | |
| SCHEMBL29676965 | 0.72 | MAPK1 (0.64) | MAPK1NAMPTGPR119ESR2HDAC1 | |
| SCHEMBL29479856 | 0.71 | BCHE (0.62) | BCHEMAPK1NAMPTKDM1AMEN1 | |
| SCHEMBL21505062 | 0.70 | MAPK1 (0.59) | BCHEMAPK1NAMPTLIPGGPR119 | |
| SCHEMBL13502703 | 0.70 | KDM4E (0.47) | BCHEMAPK1NAMPTKDM1AMEN1 | |
| SCHEMBL3429052 | 0.69 | MAPK1 (0.51) | BCHEMAPK1NAMPTKDM1AGPR119 | |
| SCHEMBL30900483 | 0.69 | NOTUM (0.61) | KDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408761-A1 | SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | Schering Corporation (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2303893-A1 | TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF | Schering Corporation (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2197842-A1 | 2, 3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | SCHERING CORPORATION (US) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009152200-A1 | TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009032124-A1 | SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032116-A1 | 2, 3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |