Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 17/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310010 | 0.91 | AVPR1B (0.57) | AVPR1BMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL4302641 | 0.90 | AVPR1B (0.54) | AVPR1BMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL8024583 | 0.87 | AVPR1B (0.73) | AVPR1B | |
| SCHEMBL4307444 | 0.84 | AVPR1B (0.76) | AVPR1B | |
| SCHEMBL4305913 | 0.81 | AVPR1B (0.40) | AVPR1BKDM4E | |
| SCHEMBL4311760 | 0.75 | TNKS (0.39) | AVPR1BMAPTKDM4E | |
| SCHEMBL4304225 | 0.74 | AVPR1B (0.80) | AVPR1B | |
| SCHEMBL4302704 | 0.74 | AVPR1B (0.81) | AVPR1B | |
| SCHEMBL8010966 | 0.74 | AVPR1B (0.80) | AVPR1B | |
| SCHEMBL8018283 | 0.72 | AVPR1B (0.41) | AVPR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |