Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930104 | 0.82 | IGF1R (0.53) | IGF1RFGFR1KDR | |
| SCHEMBL3934000 | 0.82 | IGF1R (0.65) | IGF1RFGFR1KDR | |
| SCHEMBL4161724 | 0.82 | IGF1R (0.65) | IGF1RFGFR1KDR | |
| SCHEMBL4010595 | 0.79 | IGF1R (0.60) | IGF1RFGFR1KDR | |
| SCHEMBL5110595 | 0.78 | IGF1R (0.59) | IGF1RFGFR1KDR | |
| SCHEMBL4010335 | 0.76 | IGF1R (0.55) | IGF1RFGFR1KDR | |
| SCHEMBL4014128 | 0.72 | IGF1R (0.51) | IGF1RFGFR1KDR | |
| SCHEMBL4009835 | 0.71 | IGF1R (0.69) | IGF1RFGFR1KDRNTRK1CDK2 | |
| SCHEMBL3926892 | 0.68 | IGF1R (0.50) | IGF1RFGFR1KDR | |
| SCHEMBL3939418 | 0.68 | IGF1R (0.63) | IGF1RFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |