Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.80 |
| ▸ | REN | P00797 | 5/20 | 0.80 |
| ▸ | CTSD | P07339 | 5/20 | 0.80 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2795477 | 0.94 | BACE1 (0.90) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL2791153 | 0.89 | BACE1 (1.00) | BACE1RENCTSDBACE2 | |
| SCHEMBL2795468 | 0.89 | BACE1 (1.00) | BACE1RENCTSDBACE2 | |
| SCHEMBL2795258 | 0.89 | BACE1 (1.00) | BACE1RENCTSDBACE2 | |
| SCHEMBL2792076 | 0.89 | BACE1 (0.82) | BACE1RENCTSDBACE2 | |
| SCHEMBL4317270 | 0.88 | BACE1 (0.80) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL2792254 | 0.87 | BACE1 (0.73) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL15956680 | 0.86 | BACE1 (1.00) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL4307236 | 0.85 | BACE1 (0.76) | BACE1RENCTSDBACE2 | |
| SCHEMBL2792974 | 0.85 | BACE1 (1.00) | BACE1RENCTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012139-A1 | AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-01-08 | — | — | US | disclosed |
| CN-101273018-A | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (BACE) | WYETH CORP (US) | 2008-09-24 | — | — | CN | disclosed |
| US-7423158-B2 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase | WYETH (US) | 2008-09-09 | — | — | US | disclosed |
| US-20070072925-A1 | Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase | WYETH (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012139-A1 | AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | BACE1 1/4885REN 2314/4885CTSD 98/4885 |
| US-20070072925-A1 | Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase | BACE1, BACE2, APP | BACE1 1/4885REN 2687/4885CTSD 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.