Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300281 | 0.89 | HSD17B10 (0.47) | HSD17B10KDM4EALOX15PDE5AHPGD | |
| SCHEMBL4306792 | 0.88 | HPGD (0.45) | HSD17B10KDM4EALOX15PDE5AHPGD | |
| SCHEMBL273992 | 0.88 | ELANE (0.53) | HSD17B10KDM4EHPGDTSHRKMT2A | |
| SCHEMBL4302795 | 0.85 | ABCG2 (0.43) | KMT2AMEN1 | |
| SCHEMBL5733404 | 0.83 | NR1H4 (0.49) | — | |
| SCHEMBL29881780 | 0.83 | NR1H4 (0.49) | — | |
| SCHEMBL687916 | 0.82 | NR1H4 (0.50) | KMT2AMEN1 | |
| SCHEMBL29880554 | 0.82 | NR1H4 (0.50) | KMT2AMEN1 | |
| SCHEMBL274076 | 0.81 | NR1H4 (0.52) | HSD17B10KDM4EALOX15PDE5AHPGD | |
| SCHEMBL4301576 | 0.79 | NR1H4 (0.56) | HSD17B10KDM4EALOX15PDE5AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595311-B2 | Modulating active of receptors; therapy prevention of disease such aas symthrome X, antidiabetic agents, insulin resistance, hypoglycemic agents | EXELIXIS, INC. (US) | 2009-09-29 | — | — | US | claimed |