Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.44 |
| ▸ | PARP1 | P09874 | 4/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MPL | P40238 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4308276 | 0.78 | TNKS (0.46) | TNKSTNKS2PARP1PDE3BPDE3A | |
| SCHEMBL4306414 | 0.75 | AVPR1B (0.47) | TNKSTNKS2PARP1PDE3BPDE3A | |
| SCHEMBL29977039 | 0.70 | TNKS (0.48) | TNKSTNKS2PARP1PDE3BPDE3A | |
| SCHEMBL23112597 | 0.70 | TNKS (0.48) | TNKSTNKS2PARP1PDE3BPDE3A | |
| SCHEMBL23112408 | 0.70 | TNKS (0.47) | TNKSTNKS2PARP1ALDH1A1GAA | |
| SCHEMBL15286944 | 0.69 | TNKS (0.49) | TNKSTNKS2PARP1KDM4E | |
| SCHEMBL29978155 | 0.69 | TNKS (0.47) | TNKSTNKS2PARP1 | |
| SCHEMBL4302614 | 0.68 | F2RL3 (0.46) | F2RL3GRIN2BGRIN1MPLKMO | |
| SCHEMBL23112734 | 0.68 | TNKS (0.45) | TNKSTNKS2PARP1PDE3BPDE3A | |
| SCHEMBL29977015 | 0.68 | TNKS (0.45) | TNKSTNKS2PARP1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |