Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 9/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 7/20 | 0.39 |
| ▸ | PDE1A | P54750 | 6/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16748877 | 0.92 | PDE1C (0.44) | PDE1CPDE1BPDE1ATNK2 | |
| SCHEMBL400651 | 0.88 | PDE1C (0.43) | PDE1CPDE1BPDE1ATNK2 | |
| SCHEMBL18099738 | 0.86 | PDE1C (0.46) | PDE1CPDE1BPDE1ATNK2 | |
| SCHEMBL13962521 | 0.85 | PDE1C (0.47) | PDE1CPDE1BPDE1ATNK2 | |
| SCHEMBL8399329 | 0.83 | PDE1C (0.37) | PDE1CPDE1BPDE1ATNK2 | |
| SCHEMBL2327173 | 0.82 | PDE1C (0.50) | PDE1CPDE1BPDE1A | |
| SCHEMBL13962531 | 0.82 | PDE1C (0.37) | PDE1CPDE1BPDE1ATNK2 | |
| SCHEMBL397982 | 0.82 | PDE1C (0.43) | PDE1CPDE1BPDE1ATNK2 | |
| SCHEMBL397983 | 0.82 | PDE1C (0.43) | PDE1CPDE1BPDE1ATNK2 | |
| SCHEMBL23217412 | 0.81 | PDE1C (0.42) | PDE1CPDE1BPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283020-B1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI PHARM INC (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2009148916-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009143051-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |