SCHEMBL4314099

SCHEMBL4314099

CCc1nc2ccc(NC(=O)c3ccc(CC(F)(F)c4ccccn4)cc3)cn2c1C

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 18/20 0.48
PTGDR2 Q9Y5Y4 1/20 0.39
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4315866 0.82 MCHR1 (0.53) MCHR1MEN1NPC1RAB9AKMT2A
SCHEMBL4311327 0.81 MCHR1 (0.48) MCHR1PTGDR2MEN1NPC1RAB9A
SCHEMBL4315883 0.81 MCHR1 (0.49) MCHR1MEN1NPC1RAB9AKMT2A
SCHEMBL4323040 0.80 MCHR1 (0.47) MCHR1PTGDR2MEN1NPC1RAB9A
SCHEMBL4322866 0.80 MCHR1 (0.51) MCHR1MEN1NPC1RAB9AKMT2A
SCHEMBL4322877 0.80 MCHR1 (0.51) MCHR1MEN1NPC1RAB9AKMT2A
SCHEMBL4322876 0.80 MCHR1 (0.51) MCHR1MEN1NPC1RAB9AKMT2A
SCHEMBL4316326 0.79 MCHR1 (0.49) MCHR1MEN1NPC1RAB9AKMT2A
SCHEMBL4316323 0.79 MCHR1 (0.49) MCHR1MEN1NPC1RAB9AKMT2A
SCHEMBL4320928 0.79 MCHR1 (0.49) MCHR1MEN1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7566781-B2 Imidazopyridine compound BANYU PHARMACEUTICAL CO., LTD. (JP) 2009-07-28 US disclosed
US-7566781-B2 Imidazopyridine compound BANYU PHARMACEUTICAL CO., LTD. (JP) 2009-07-28 US disclosed
US-7566781-B2 Imidazopyridine compound BANYU PHARMACEUTICAL CO., LTD. (JP) 2009-07-28 US disclosed
US-20070249659-A1 melanin concentrating hormone receptor antagonist; preventing or treating vascular system diseases, nervous system disorders, metabolic disorders, urogenital diseases, respiratory diseases disorders; N-(2-ethyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-fluoro-4-(pyridin-2-ylmethoxy)benzamide BANYU PHARMACEUTICAL., LTD. (JP) 2007-10-25 US disclosed
EP-1748048-A1 IMIDAZOPYRIDINE COMPOUND BANYU PHARMACEUTICAL CO., LTD. (JP) 2007-01-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249659-A1 melanin concentrating hormone receptor antagonist; preventing or treating vascular system diseases, nervous system disorders, metabolic disorders, urogenital diseases, respiratory diseases disorders; N-(2-ethyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-fluoro-4-(pyridin-2-ylmethoxy)benzamide MC1R, MCHR2, MCHR1 MCHR1 3/4885PTGDR2 197/4885MEN1 517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.