Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4319683 | 1.00 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL11921644 | 1.00 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL4319687 | 1.00 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL4317903 | 1.00 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL4317851 | 0.98 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL4317012 | 0.97 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL4325699 | 0.95 | HRH3 (0.94) | HRH3KCNH2 | |
| SCHEMBL4322212 | 0.89 | HRH3 (0.80) | HRH3KCNH2 | |
| SCHEMBL4325638 | 0.87 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL4320098 | 0.87 | HRH3 (1.00) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236792-B2 | Substituted pyrrolidine amides as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-07 | — | — | US | claimed |
| WO-2009143153-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-26 | — | — | WO | claimed |
| US-20090291903-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-11-26 | — | — | US | claimed |
| US-8236792-B2 | Substituted pyrrolidine amides as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-07 | — | — | US | disclosed |
| US-8236792-B2 | Substituted pyrrolidine amides as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-07 | — | — | US | disclosed |
| US-8236792-B2 | Substituted pyrrolidine amides as modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-07 | — | — | US | disclosed |
| WO-2009143153-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-26 | — | — | WO | disclosed |
| US-20090291903-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-11-26 | — | — | US | disclosed |
| US-20090291903-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-11-26 | — | — | US | disclosed |
| US-20090291903-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291903-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH2 | HRH3 1/4885KCNH2 1338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.