⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28371188 | 0.95 | — | — | |
| SCHEMBL945855 | 0.70 | — | — | |
| SCHEMBL3110943 | 0.70 | — | — | |
| SCHEMBL7861148 | 0.70 | — | — | |
| SCHEMBL4953700 | 0.70 | — | — | |
| SCHEMBL11659736 | 0.70 | — | — | |
| SCHEMBL27114 | 0.70 | — | — | |
| SCHEMBL1038664 | 0.70 | — | — | |
| SCHEMBL28452066 | 0.68 | — | — | |
| SCHEMBL25943 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 940 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072521-B | ROR gamma t inhibitor and application thereof in medicines | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | claimed |
| US-11208418-B2 | Nitrogenous tricyclic compounds and uses thereof in medicine | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-12-28 | — | — | US | claimed |
| CN-113072521-A | ROR gamma t inhibitor and application thereof in medicine | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | claimed |
| CN-112513021-A | ROR gamma antagonist and application thereof in medicine | 广东东阳光药业有限公司 | 2021-03-16 | — | — | CN | claimed |
| CN-110128432-B | Nitrogenous tricyclic compound and application thereof in medicine | 广东东阳光药业有限公司 | 2021-03-02 | — | — | CN | claimed |
| US-20200392146-A1 | NITROGENOUS TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-12-17 | — | — | US | claimed |
| CN-110759963-A | Condensed ring compound and preparation method and application thereof | 中山大学 | 2020-02-07 | — | — | CN | claimed |
| CN-110128432-A | Tricyclic nitrogen containing compounds and its application in drug | 广东东阳光药业有限公司 | 2019-08-16 | — | — | CN | claimed |
| US-10028942-B2 | 3-substituted pyrazoles and uses thereof | GENENTECH, INC. (US) | 2018-07-24 | — | — | US | claimed |
| EP-2945938-B1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-07 | — | — | EP | claimed |
| US-20170087137-A1 | 3-SUBSTITUTED PYRAZOLES AND USES THEREOF | GENENTECH, INC. (US) | 2017-03-30 | — | — | US | claimed |
| US-9550777-B2 | 3-substituted pyrazoles and use as DLK inhibitors | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | claimed |
| CN-105294520-A | 2-(2 ', 2'-difluoro-ethoxy)-6-trifluoromethyl-phenylpropyl sulfur ether synthesis process | DALIAN JOIN KING BIOCHEM TECH CO LTD | 2016-02-03 | — | — | CN | claimed |
| CN-105294515-A | Preparation method of 2-(2',2'-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride | TIANJIN MODERN VOCATIONAL TECHNOLOGY COLLEGE | 2016-02-03 | — | — | CN | claimed |
| US-20160002228-A1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | GENENTECH, INC. (US) | 2016-01-07 | — | — | US | claimed |
| EP-1971601-B1 | N4-PHENYL-QUINAZOLINE-4 -AMINE DERIVATIVES AND RELATED COMPOUNDS AS ERBB TYPE I RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | ARRAY BIOPHARMA INC (US) | 2009-10-21 | — | — | EP | claimed |
| US-6376493-B1 | SELECTIVE INHIBITION OF PHOSPHODIESTERASE IV AND TUMOR NECROSIS FACTOR; USEFUL IN TREATING OSTEOPOROSIS, TUMORS, AUTOIMMUNE DISEASES, RHEUMATIC DISEASES, AND ASTHMA | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-04-23 | — | — | US | claimed |
| US-20240238425-A1 | HSD17B13 Inhibitors and/or Degraders | PFIZER INC. (US) | 2024-07-18 | — | — | US | disclosed |
| EP-0458361-A1 | Pyridine derivatives, their production processes and their compositions for the control of insect pests | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-11-27 | — | — | EP | disclosed |
| EP-0355759-A2 | Plant-protecting agents | BASF Aktiengesellschaft (DE) | 1990-02-28 | — | — | EP | disclosed |