Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.73 |
| ▸ | MTOR | P42345 | 5/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.73 |
| ▸ | TYR | P14679 | 2/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314988 | 1.00 | PIK3CA (0.73) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL4325326 | 0.92 | PIK3CA (0.67) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL4325330 | 0.92 | PIK3CA (0.67) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL4322414 | 0.88 | PIK3CA (0.71) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL1429464 | 0.88 | PIK3CA (0.71) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL4327546 | 0.86 | PIK3CA (0.60) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL1429579 | 0.86 | PIK3CA (0.60) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL4315159 | 0.86 | PIK3CA (0.60) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL1429429 | 0.86 | PIK3CA (0.60) | PIK3CAMTORPIK3CGTYRPTGS2 | |
| SCHEMBL1428914 | 0.86 | PIK3CA (0.60) | PIK3CAMTORPIK3CGTYRPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, RICTOR, PDPK1 | PIK3CA 4/4885MTOR 1/4885PIK3CG 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.