SCHEMBL4315948

SCHEMBL4315948

CN1CCC(N(C)c2ccc(N)cn2)CC1.COc1cc(OC)c(Cl)c(-c2ccc(C(=O)O)c3nccnc23)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 20/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12678245 0.85 FGFR3 (0.68) FGFR3
SCHEMBL3313648 0.81 FGFR3 (0.71) FGFR3
SCHEMBL4315945 0.81 FGFR3 (0.40) FGFR3
SCHEMBL17023107 0.80 FGFR3 (0.53) FGFR3
SCHEMBL3316006 0.79 FGFR3 (0.62) FGFR3
SCHEMBL3316940 0.77 FGFR3 (0.59) FGFR3
SCHEMBL3314711 0.77 FGFR3 (0.49) FGFR3
SCHEMBL1126061 0.77 FGFR3 (0.61) FGFR3
4-Aminophenol SCHEMBL3316909 0.76 FGFR3 (0.54) FGFR3
SCHEMBL3317394 0.75 FGFR3 (0.72) FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009141386-A1 DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2009-11-26 WO claimed