Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 20/20 | 0.73 |
| ▸ | BRAF | P15056 | 20/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | AKT1 | P31749 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4316690 | 0.89 | KIT (0.76) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4316706 | 0.88 | KIT (0.79) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4308274 | 0.88 | KIT (0.73) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4312332 | 0.86 | KIT (0.72) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4305954 | 0.86 | KIT (0.75) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4307151 | 0.86 | KIT (0.72) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4313005 | 0.86 | KIT (0.80) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4306516 | 0.85 | KIT (0.76) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4305949 | 0.85 | KIT (0.77) | KITBRAFMAPK1AKT1KDR | |
| SCHEMBL4307187 | 0.85 | KIT (0.69) | KITBRAFMAPK1AKT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023753-A1 | 1,3-Thiazole-5-Carboxamides Useful as Cancer Chemotherapeutic Agents | BAYER HEALTHCARE AG (DE) | 2009-01-22 | — | — | US | disclosed |
| US-20090023753-A1 | 1,3-Thiazole-5-Carboxamides Useful as Cancer Chemotherapeutic Agents | BAYER HEALTHCARE AG (DE) | 2009-01-22 | — | — | US | disclosed |
| US-20090023753-A1 | 1,3-Thiazole-5-Carboxamides Useful as Cancer Chemotherapeutic Agents | BAYER HEALTHCARE AG (DE) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023753-A1 | 1,3-Thiazole-5-Carboxamides Useful as Cancer Chemotherapeutic Agents | MCL1, HDAC5, HDAC6 | KIT 2658/4885BRAF 1099/4885MAPK1 3210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.