Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314917 | 0.91 | HRH3 (0.64) | HRH3KCNH2 | |
| SCHEMBL4314919 | 0.90 | HRH3 (0.66) | HRH3KCNH2 | |
| SCHEMBL4320815 | 0.87 | HRH3 (0.55) | HRH3KCNH2 | |
| SCHEMBL4450674 | 0.87 | HRH3 (0.56) | HRH3KCNH2 | |
| SCHEMBL11921652 | 0.82 | HRH3 (0.68) | HRH3KCNH2 | |
| SCHEMBL4325712 | 0.82 | HRH3 (0.68) | HRH3KCNH2 | |
| SCHEMBL11921653 | 0.81 | HRH3 (0.67) | HRH3KCNH2 | |
| SCHEMBL4317820 | 0.81 | HRH3 (0.67) | HRH3KCNH2 | |
| SCHEMBL17237594 | 0.81 | HRH3 (0.60) | HRH3KDM4EALDH1A1 | |
| SCHEMBL4328864 | 0.79 | HRH3 (0.69) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143153-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-26 | — | — | WO | claimed |
| WO-2009143153-A1 | SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-26 | — | — | WO | disclosed |