Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4319461 | 1.00 | NPC1 (0.59) | NPC1RAB9AAKR1C3HRH4MEN1 | |
| SCHEMBL4319456 | 1.00 | NPC1 (0.59) | NPC1RAB9AAKR1C3HRH4MEN1 | |
| Hydrochloric Acid SCHEMBL4472537 | 0.99 | NPC1 (0.58) | NPC1RAB9AAKR1C3HRH4MEN1 | |
| Hydrochloric Acid SCHEMBL4472534 | 0.99 | NPC1 (0.58) | NPC1RAB9AAKR1C3HRH4MEN1 | |
| Hydrochloric Acid SCHEMBL4472544 | 0.99 | NPC1 (0.58) | NPC1RAB9AAKR1C3HRH4MEN1 | |
| SCHEMBL4476320 | 0.87 | HRH4 (0.54) | NPC1RAB9AHRH4MEN1KMT2A | |
| SCHEMBL4318604 | 0.87 | HRH4 (0.65) | RAB9AHRH4MEN1KMT2APOLB | |
| SCHEMBL4338442 | 0.87 | HRH4 (0.54) | NPC1RAB9AHRH4MEN1KMT2A | |
| SCHEMBL4318603 | 0.87 | HRH4 (0.65) | RAB9AHRH4MEN1KMT2APOLB | |
| SCHEMBL4322536 | 0.87 | HRH4 (0.65) | RAB9AHRH4MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010172-B1 | INDOLES AND BENZOIMIDAZOLES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-29 | — | — | EP | claimed |
| US-7544698-B2 | Indoles and benzoimidazoles as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-06-09 | — | — | US | claimed |
| EP-2010172-A2 | INDOLES AND BENZOIMIDAZOLES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-01-07 | — | — | EP | claimed |
| WO-2007117401-A2 | INDOLES AND BENZOIMIDAZOLES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-18 | — | — | WO | claimed |
| US-20070238771-A1 | Indoles and benzoimidazoles as histamine H4 receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238771-A1 | Indoles and benzoimidazoles as histamine H4 receptor modulators | HRH4, HRH3, HRH1 | NPC1 3718/4885RAB9A 4006/4885AKR1C3 2119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.