Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 9/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177843 | 0.89 | CSF1R (0.61) | CSF1RCYP2C9KITCYP2C19NTRK1 | |
| SCHEMBL2178174 | 0.88 | CSF1R (0.61) | CSF1RCYP2C9KITCYP2C19NTRK1 | |
| SCHEMBL2907600 | 0.81 | CSF1R (0.64) | CSF1RCYP2C9KITCYP2C19NTRK1 | |
| SCHEMBL2176884 | 0.81 | CSF1R (0.61) | CSF1RCYP2C9KITCYP2C19CYP3A4 | |
| SCHEMBL2909875 | 0.81 | KIT (0.52) | CSF1RCYP2C9KITCYP2C19NTRK1 | |
| Trifluoroacetic Acid SCHEMBL2178216 | 0.81 | CSF1R (0.49) | CSF1RCYP2C9KITCYP2C19NTRK1 | |
| SCHEMBL3086038 | 0.80 | CSF1R (0.63) | CSF1RCYP2C9KITCYP2C19NTRK1 | |
| SCHEMBL14093079 | 0.80 | CSF1R (0.63) | CSF1RKITCYP2C19NTRK1LCK | |
| SCHEMBL1861602 | 0.80 | CSF1R (0.55) | CSF1RKITCYP2C19NTRK1LCK | |
| SCHEMBL12668845 | 0.79 | CSF1R (0.58) | CSF1RKITCYP2C19NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021335-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124316-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |