Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 10/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.42 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.42 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320715 | 1.00 | HRH3 (0.52) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4320884 | 0.98 | HRH3 (0.55) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4309015 | 0.97 | HRH3 (0.54) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4309013 | 0.97 | HRH3 (0.54) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4315514 | 0.96 | HRH3 (0.55) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4305664 | 0.95 | HRH3 (0.54) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4307524 | 0.94 | HRH3 (0.55) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4326787 | 0.93 | HRH3 (0.49) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4326790 | 0.93 | HRH3 (0.49) | HRH3KCNH2HTR1ASLC6A4HRH1 | |
| SCHEMBL4318056 | 0.92 | HRH3 (0.55) | HRH3KCNH2HTR1ASLC6A4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069370-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-12 | — | — | US | claimed |
| US-20090069370-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069370-A1 | AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH1, HRH2 | HRH3 4/4885KCNH2 456/4885HTR1A 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.