Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 1.00 |
| ▸ | MTOR | P42345 | 12/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 12/20 | 1.00 |
| ▸ | ABCC2 | Q92887 | 7/20 | 0.78 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.60 |
| ▸ | TUBB | P07437 | 1/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.60 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.60 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.60 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.60 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.60 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.60 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.60 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.60 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.60 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.60 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4322312 | 1.00 | PIK3CA (1.00) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL4315105 | 0.98 | PIK3CA (0.97) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL4315097 | 0.98 | PIK3CA (0.97) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL4316078 | 0.92 | PIK3CA (1.00) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL1428244 | 0.92 | PIK3CA (1.00) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL1429010 | 0.90 | PIK3CA (0.87) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL4320514 | 0.90 | PIK3CA (0.87) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL1428577 | 0.90 | PIK3CA (0.92) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL4328316 | 0.90 | PIK3CA (0.92) | PIK3CAMTORPIK3CGABCC2TUBB4A | |
| SCHEMBL4320475 | 0.88 | PIK3CA (0.80) | PIK3CAMTORPIK3CGABCC2TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-17 | — | — | US | claimed |
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, RICTOR, PDPK1 | PIK3CA 4/4885MTOR 1/4885PIK3CG 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.