⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215897 | 0.65 | — | — | |
| SCHEMBL3754347 | 0.65 | — | — | |
| SCHEMBL4328507 | 0.65 | — | — | |
| SCHEMBL563998 | 0.63 | — | — | |
| SCHEMBL11883487 | 0.63 | — | — | |
| SCHEMBL11137968 | 0.63 | — | — | |
| SCHEMBL8056119 | 0.63 | — | — | |
| SCHEMBL6550677 | 0.60 | — | — | |
| SCHEMBL8418471 | 0.60 | — | — | |
| SCHEMBL15233768 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356344-B1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY | ASTEX THERAPEUTICS LTD (GB) | 2022-11-16 | — | — | EP | disclosed |
| CN-108473464-B | Isoindolinone inhibitors of MDM2-P53 interaction with anti-cancer activity | 阿斯泰克斯治疗有限公司 | 2022-08-23 | — | — | CN | disclosed |
| US-20220106287-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2022-04-07 | — | — | US | disclosed |
| US-11261171-B1 | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity | ASTEX THERAPEUTICS LIMITED (GB) | 2022-03-01 | — | — | US | disclosed |
| CN-109970752-B | Synthesis method of chiral 4-spiro pyrazole compound | 浙江工业大学 | 2020-11-13 | — | — | CN | disclosed |
| CN-109970752-A | A kind of synthetic method of chirality 4- loop coil pyrazole compound | 浙江工业大学 | 2019-07-05 | — | — | CN | disclosed |
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
| CN-101128435-A | Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |
| EP-1833800-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |
| EP-0087388-B1 | PYRAZOLONE COUPLERS AND COLOUR PHOTOGRAPHIC SILVER HALIDE RECORDING MATERIAL CONTAINING THEM | CIBA-GEIGY AG (CH) | 1986-06-25 | — | — | EP | disclosed |
| EP-0087388-A1 | Pyrazolone couplers and colour photographic silver halide recording material containing them | CIBA-GEIGY AG (CH) | 1983-08-31 | — | — | EP | disclosed |
| US-4262087-A | USING TWO EQUIVALENTS OF SILVER | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1981-04-14 | — | — | US | disclosed |