Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.46 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853829 | 0.94 | SPHK1 (0.44) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL6424097 | 0.91 | SPHK1 (0.47) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL4669838 | 0.91 | PPARG (0.43) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL1852778 | 0.90 | SPHK1 (0.42) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL1855446 | 0.89 | SPHK1 (0.42) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL1852747 | 0.88 | PPARG (0.45) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL1852027 | 0.85 | PPARG (0.43) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL1852532 | 0.85 | PPARG (0.43) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL1854788 | 0.84 | SPHK1 (0.45) | SPHK1SPHK2PPARGPPARAPPARD | |
| SCHEMBL1854066 | 0.84 | SPHK1 (0.45) | SPHK1SPHK2PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592477-B2 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases (PTPs) | LABORATOIRES SERONO SA (CH) | 2009-09-22 | — | — | US | disclosed |
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | APPLIED RESEARCH SYSTEMS ARS (NL) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | PTPRS, PTPA, PTPMT1 | SPHK1 2279/4885SPHK2 2550/4885PPARG 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.