SCHEMBL4326795

SCHEMBL4326795

C[C@@](O)(C(=O)O)c1ccccc1.C[C@@](O)(C(=O)O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.52
KMT2A Q03164 1/20 0.52
CYP1A2 P05177 2/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.50
HIF1A Q16665 1/20 0.50
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48
KCNN4 O15554 1/20 0.45
CYP2C9 P11712 1/20 0.45
ALDH1A1 P00352 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL153694 1.00 MAPT (0.52) MAPTKMT2ACYP1A2CYP2D6CYP2C19
SCHEMBL21557850 1.00 MAPT (0.52) MAPTKMT2ACYP1A2CYP2D6CYP2C19
SCHEMBL197251 1.00 MAPT (0.52) MAPTKMT2ACYP1A2CYP2D6CYP2C19
SCHEMBL198241 1.00 MAPT (0.52) MAPTKMT2ACYP1A2CYP2D6CYP2C19
SCHEMBL31598893 0.98 CYP1A2 (0.50) MAPTKMT2ACYP1A2CYP2D6CYP2C19
Water SCHEMBL6414988 0.98 CYP1A2 (0.50) MAPTKMT2ACYP1A2CYP2D6CYP2C19
Iodide SCHEMBL3861799 0.98 CYP1A2 (0.50) MAPTKMT2ACYP1A2CYP2D6CYP2C19
Phosphine SCHEMBL29088066 0.98 CYP1A2 (0.50) MAPTKMT2ACYP1A2CYP2D6CYP2C19
Water SCHEMBL7613695 0.98 CYP1A2 (0.50) MAPTKMT2ACYP1A2CYP2D6CYP2C19
SCHEMBL29733105 0.98 CYP1A2 (0.50) MAPTKMT2ACYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2511844-B1 X-ray microscope XRPRO SCIENCES INC (US) 2015-08-12 EP disclosed
EP-2084519-B1 X-RAY FLUORESCENCE ANALYSIS METHOD LOS ALAMOS NAT SECURITY LLC (US) 2012-08-01 EP disclosed
EP-2084519-A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING Los Alamos National Security, LLC (US) 2009-08-05 EP disclosed
WO-2008127291-A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING LOS ALAMOS NATIONAL SECURITY, LLC (US) 2008-10-23 WO disclosed