Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.48 |
| ▸ | MTOR | P42345 | 18/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330181 | 0.94 | PIK3CA (0.53) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL4318705 | 0.89 | PIK3CA (0.51) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL4315819 | 0.89 | PIK3CA (0.52) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL4328358 | 0.87 | PIK3CA (0.48) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL4314955 | 0.86 | PIK3CA (0.47) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL4323424 | 0.86 | PIK3CA (0.51) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL1428644 | 0.86 | PIK3CA (0.65) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL1429059 | 0.86 | PIK3CA (0.65) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL4321631 | 0.85 | PIK3CA (0.51) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL1429277 | 0.80 | PIK3CA (0.64) | PIK3CAMTORPIK3CGPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, RICTOR, PDPK1 | PIK3CA 4/4885MTOR 1/4885PIK3CG 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.