SCHEMBL4330440

SCHEMBL4330440

N=C(N)c1ccc2cc(C(=O)Nc3ccc(CN)cc3)ccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PLAU P00749 18/20 1.00
▸ PLG P00747 9/20 1.00
▸ PRSS1 P07477 8/20 1.00
▸ KLKB1 P03952 7/20 1.00
▸ PLAT P00750 7/20 1.00
▸ F2 P00734 7/20 0.80
▸ KLK1 P06870 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27570127 0.93 PLAU (0.87) PLAUPLGPRSS1KLKB1PLAT
Trifluoroacetic Acid SCHEMBL7344122 0.92 PLAU (0.84) PLAUPLGPRSS1KLKB1PLAT
SCHEMBL7345234 0.89 PLAU (1.00) PLAUPLGPRSS1KLKB1PLAT
SCHEMBL7345572 0.88 PLAU (1.00) PLAUPLGPRSS1KLKB1PLAT
SCHEMBL7345540 0.88 PLAU (0.78) PLAUPLGPRSS1KLKB1PLAT
SCHEMBL7340321 0.85 PLAU (1.00) PLAUPLGPRSS1KLKB1PLAT
Trifluoroacetic Acid SCHEMBL7335882 0.85 PLAU (0.74) PLAUPLGPRSS1KLKB1PLAT
SCHEMBL27536267 0.84 PLAU (0.81) PLAUPLGPRSS1KLKB1PLAT
SCHEMBL6439031 0.84 PLAU (0.72) PLAUPLGPRSS1KLKB1PLAT
SCHEMBL7336455 0.83 PLAU (0.78) PLAUPLGPRSS1KLKB1PLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6284796-B1 NAPHTHAMIDINE COMPOUNDS ABBOTT LABORATORIES 2001-09-04 — — US claimed
EP-3681504-B1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN INC (US) 2023-08-23 — — EP disclosed
US-11573224-B2 Methods of detection using X-ray fluorescence ICAGEN, LLC (US) 2023-02-07 — — US disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 — — US disclosed
US-10877035-B2 Advanced drug development and manufacturing ICAGEN, LLC (US) 2020-12-29 — — US disclosed
US-20200278346-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ADJACENT ACQUISITION CO., LLC 2020-09-03 — — US disclosed
EP-3681504-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE Icagen, Inc. (US) 2020-07-22 — — EP disclosed
WO-2019055754-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN, INC. (US) 2019-03-21 — — WO disclosed
US-20150309021-A1 Advanced Drug Development and Manufacturing LOS ALAMOS NATIONAL SECURITY, LLC 2015-10-29 — — US disclosed
EP-2511844-B1 X-ray microscope XRPRO SCIENCES INC (US) 2015-08-12 — — EP disclosed
EP-2511844-A2 Advanced drug development and manufacturing Los Alamos National Security, LLC (US) 2012-10-17 — — EP disclosed
EP-2084519-B1 X-RAY FLUORESCENCE ANALYSIS METHOD LOS ALAMOS NAT SECURITY LLC (US) 2012-08-01 — — EP disclosed
EP-2084519-A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING Los Alamos National Security, LLC (US) 2009-08-05 — — EP disclosed
WO-2008127291-A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING LOS ALAMOS NATIONAL SECURITY, LLC (US) 2008-10-23 — — WO disclosed
US-20080220441-A1 Advanced drug development and manufacturing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2008-09-11 — — US disclosed
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