Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 3/20 | 0.57 |
| ▸ | GSK3B | P49841 | 3/20 | 0.57 |
| ▸ | CDK4 | P11802 | 10/20 | 0.52 |
| ▸ | CCND1 | P24385 | 10/20 | 0.52 |
| ▸ | CDK11A | Q9UQ88 | 8/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.52 |
| ▸ | CDK9 | P50750 | 8/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336187 | 0.92 | GSK3A (0.63) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4331367 | 0.91 | GSK3A (0.62) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4337149 | 0.91 | CDK4 (0.52) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4342717 | 0.90 | CDK4 (0.57) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4335185 | 0.90 | CDK4 (0.55) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4336027 | 0.90 | CDK4 (0.54) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4336196 | 0.90 | CCNA2 (0.55) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4342199 | 0.87 | CCNA2 (0.56) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4331555 | 0.86 | CDK4 (0.51) | GSK3AGSK3BCDK4CCND1CDK11A | |
| SCHEMBL4333612 | 0.86 | CDK4 (0.51) | GSK3AGSK3BCDK4CCND1CDK11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740576-B1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | claimed |
| US-7211576-B2 | Diaminothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | claimed |
| US-20050239843-A1 | Diaminothiazoles | DING QINGJIE | 2005-10-27 | — | — | US | claimed |
| EP-1740576-B1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |
| US-7211576-B2 | Diaminothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-7211576-B2 | Diaminothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-7211576-B2 | Diaminothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-20050239843-A1 | Diaminothiazoles | DING QINGJIE | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239843-A1 | Diaminothiazoles | CDK4, CDK2, CDK1 | GSK3A 680/4885GSK3B 633/4885CDK4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.