Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1549670 | 0.92 | PARP1 (0.45) | PARP1GAA | |
| SCHEMBL1549734 | 0.91 | PARP1 (0.44) | PARP1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL1549034 | 0.87 | PARP1 (0.41) | PARP1ADORA2AADORA1KDM4E | |
| SCHEMBL4330288 | 0.86 | PARP1 (0.42) | PARP1RAD52KDM4EALDH1A1 | |
| SCHEMBL1549414 | 0.84 | PARP1 (0.59) | PARP1TNKSADORA2AKDM4EALDH1A1 | |
| SCHEMBL4556469 | 0.81 | KDM4E (0.42) | PARP1TNKSRAD52ADORA2AADORA1 | |
| SCHEMBL1549386 | 0.78 | PARP1 (0.69) | PARP1TNKSKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL4326864 | 0.77 | PARP1 (0.68) | PARP1TNKSKDM4EALDH1A1 | |
| SCHEMBL14750123 | 0.77 | PARP1 (0.47) | PARP1TNKSADORA2AADORA1KDM4E | |
| SCHEMBL4330279 | 0.75 | PARP1 (0.46) | PARP1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313418-B1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | PELLICCIARI ROBERTO (IT) | 2016-03-30 | — | — | EP | disclosed |
| US-9079915-B2 | Thienyl- and furanyl-isoquinolinones and methods for using them | Pellicciari, Robert (IT) | 2015-07-14 | — | — | US | disclosed |
| US-9079915-B2 | Thienyl- and furanyl-isoquinolinones and methods for using them | Pellicciari, Robert (IT) | 2015-07-14 | — | — | US | disclosed |
| US-9079915-B2 | Thienyl- and furanyl-isoquinolinones and methods for using them | Pellicciari, Robert (IT) | 2015-07-14 | — | — | US | disclosed |
| US-20140107117-A1 | Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them | Moroni, Flavio (IT) | 2014-04-17 | — | — | US | disclosed |
| US-20140107117-A1 | Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them | Moroni, Flavio (IT) | 2014-04-17 | — | — | US | disclosed |
| US-20140107117-A1 | Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them | Moroni, Flavio (IT) | 2014-04-17 | — | — | US | disclosed |
| US-8633215-B2 | Thienyl-and furanyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2014-01-21 | — | — | US | disclosed |
| US-8633215-B2 | Thienyl-and furanyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2014-01-21 | — | — | US | disclosed |
| US-8633215-B2 | Thienyl-and furanyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2014-01-21 | — | — | US | disclosed |
| US-20090325951-A1 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090325951-A1 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090325951-A1 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
| WO-2009155413-A1 | THIENYL- AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107117-A1 | Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them | PARP1, PARP2, PARP15 | PARP1 1/4885TNKS 13/4885RAD52 110/4885 |
| US-20090325951-A1 | THIENYL-AND FURANYL-ISOQUINOLINONES AND METHODS FOR USING THEM | PARP1, PARP2, PARP15 | PARP1 1/4885TNKS 13/4885RAD52 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.