Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 13/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13577793 | 0.88 | SCN9A (0.70) | SCN9ASCN5AKCNH2 | |
| SCHEMBL13577794 | 0.85 | SCN9A (0.73) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4321096 | 0.82 | SCN9A (0.80) | SCN9ASCN5AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL4337866 | 0.79 | SCN9A (0.75) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4476223 | 0.77 | SCN9A (0.71) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4325532 | 0.74 | SCN9A (0.80) | SCN9ASCN5AKCNH2 | |
| SCHEMBL3892332 | 0.74 | SCN9A (0.84) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4332708 | 0.73 | SCN9A (1.00) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4323513 | 0.72 | SCN9A (0.81) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4325285 | 0.72 | SCN9A (1.00) | SCN9ASCN5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145721-A1 | ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | claimed |
| WO-2009145721-A1 | ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | disclosed |