Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 9/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.47 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.47 |
| ▸ | MAPKAPK3 | Q16644 | 4/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30415837 | 1.00 | MAP2K4 (0.49) | MAP2K4NTRK1CSNK1DHTR2AMAPK1 | |
| SCHEMBL27649536 | 0.83 | HTR2A (0.47) | MAP2K4CSNK1DHTR2AMAPK1MAPK6 | |
| SCHEMBL2469031 | 0.80 | AXL (0.55) | MAP2K4NTRK1CSNK1DHTR2AMAPK1 | |
| SCHEMBL14359839 | 0.80 | MAP2K4 (0.62) | MAP2K4NTRK1CSNK1DMAPK1MAPK6 | |
| SCHEMBL5374591 | 0.80 | MAP2K4 (0.71) | MAP2K4NTRK1CSNK1DMAPK1MAPK6 | |
| SCHEMBL4734012 | 0.80 | CSNK1D (0.71) | MAP2K4NTRK1CSNK1DHTR2AMAPK1 | |
| Hydrochloric Acid SCHEMBL27750634 | 0.79 | AXL (0.54) | MAP2K4NTRK1CSNK1DHTR2AMAPK1 | |
| SCHEMBL8437976 | 0.79 | MKNK1 (0.74) | MAP2K4CSNK1DMAPK1MAPK6MKNK1 | |
| SCHEMBL4324649 | 0.78 | MAP2K4 (0.50) | MAP2K4NTRK1MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL4084327 | 0.78 | MAP2K4 (0.76) | MAP2K4NTRK1CSNK1DMAPK1MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4178954-A1 | SUBSTITUTED PYRROLIDINE AMINES AND AMIDES AS MEDIATOR OF THE GLUCOCORTOID RECEPTOR | Grünenthal GmbH (DE) | 2023-05-17 | — | — | EP | disclosed |
| WO-2022008705-A1 | SUBSTITUTED PYRROLIDINE AMINES AND AMIDES AS MEDIATOR OF THE GLUCOCORTOID RECEPTOR | Grünenthal GmbH (DE) | 2022-01-13 | — | — | WO | disclosed |
| EP-3728233-A1 | SUBSTITUTED PYRROLIDINE AMIDES II | Grünenthal GmbH (DE) | 2020-10-28 | — | — | EP | disclosed |
| EP-2726464-A1 | CRYSTALLINE FORM OF INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | Astrazeneca AB (SE) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013001294-A1 | CRYSTALLINE FORM OF INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2013-01-03 | — | — | WO | disclosed |
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |