Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.72 |
| ▸ | MLYCD | O95822 | 3/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | TDO2 | P48775 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6102776 | 0.84 | MAPK14 (1.00) | MAPK14MLYCDMAPK9MAPK10MAPK11 | |
| SCHEMBL4341533 | 0.84 | MAPK14 (0.72) | MAPK14MLYCDPTGS1BRD4TDO2 | |
| SCHEMBL6090980 | 0.84 | MAPK14 (1.00) | MAPK14MLYCDMAPK9MAPK10MAPK11 | |
| SCHEMBL1878819 | 0.82 | MAPK14 (0.75) | MAPK14MLYCDPTGS1BRD4TDO2 | |
| SCHEMBL4346731 | 0.82 | MAPK14 (0.61) | MAPK14MLYCDPTGS1MAPK9MAPK10 | |
| SCHEMBL27765845 | 0.81 | MAPK14 (0.68) | MAPK14MLYCDPTGS1MAPK9MAPK10 | |
| SCHEMBL4337249 | 0.80 | MAPK14 (0.67) | MAPK14MLYCDPTGS1PTGS2NPC1 | |
| SCHEMBL4335110 | 0.80 | MAPK14 (0.67) | MAPK14MLYCDPTGS1BRD4TDO2 | |
| SCHEMBL4338473 | 0.79 | MAPK14 (0.57) | MAPK14MLYCDPTGS1BRD4TDO2 | |
| SCHEMBL1878049 | 0.78 | MAPK14 (0.74) | MAPK14MLYCDPTGS1BRD4TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101472921-B | Pyridylisoxazole derivative | ASKA PHARM CO LTD | 2012-10-10 | — | — | CN | disclosed |
| US-8207203-B2 | Pyridylisoxazole derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-20090306145-A1 | Pyridylisoxazole Derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| CN-101472921-A | Pyridylisoxazole derivative | ASKA PHARM CO LTD (JP) | 2009-07-01 | — | — | CN | disclosed |
| EP-2036905-A1 | PYRIDYLISOXAZOLE DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306145-A1 | Pyridylisoxazole Derivatives | CNKSR1, MAPK1, MAPK3 | MAPK14 43/4885MLYCD 4475/4885PTGS1 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.