Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 10/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366184 | 0.99 | F2R (0.46) | F2RKMT2AMEN1CYP3A4LMNA | |
| Bromide SCHEMBL4340057 | 0.88 | F2R (0.36) | F2RKMT2AMEN1CYP3A4LMNA | |
| Bromide SCHEMBL4340062 | 0.88 | F2R (0.36) | F2RKMT2AMEN1CYP3A4LMNA | |
| Bromide SCHEMBL4342103 | 0.87 | F2R (0.47) | F2RKMT2AMEN1CYP3A4LMNA | |
| SCHEMBL6362635 | 0.86 | F2R (0.37) | F2RKMT2AMEN1CYP3A4LMNA | |
| SCHEMBL6362636 | 0.86 | F2R (0.37) | F2RKMT2AMEN1CYP3A4LMNA | |
| SCHEMBL14369143 | 0.86 | F2R (0.36) | F2RKMT2AMEN1CYP3A4LMNA | |
| SCHEMBL14346308 | 0.86 | F2R (0.48) | F2RKMT2AMEN1CYP3A4LMNA | |
| Bromide SCHEMBL4337545 | 0.83 | F2R (0.46) | F2RKMT2AMEN1CYP3A4LMNA | |
| SCHEMBL14346336 | 0.82 | F2R (0.47) | F2RKMT2AMEN1CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391456-B1 | 2-IMINOIMIDAZOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | EP | disclosed |
| US-7304083-B2 | 2-iminoimidazole derivatives (2) | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-12-04 | — | — | US | disclosed |