Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.44 |
| ▸ | F2R | P25116 | 10/20 | 0.59 |
| ▸ | MAOB | P27338 | 6/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6365089 | 0.99 | F2R (0.60) | F2RMAOBMAOABCHEACHE | |
| SCHEMBL14369172 | 0.87 | F2R (0.51) | F2RMAOBMAOABCHEACHE | |
| Bromide SCHEMBL4340412 | 0.84 | F2R (0.62) | F2RMAOBMAOABCHEACHE | |
| SCHEMBL14346350 | 0.83 | F2R (0.63) | F2RMAOBMAOABCHEACHE | |
| Bromide SCHEMBL4347253 | 0.83 | F2R (0.67) | F2RMAOBMAOABCHEACHE | |
| SCHEMBL14346288 | 0.82 | F2R (0.69) | F2RMAOBMAOABCHEACHE | |
| SCHEMBL4339115 | 0.82 | F2R (0.61) | F2RMAOBMAOABCHEACHE | |
| Bromide SCHEMBL4340619 | 0.81 | F2R (0.64) | F2RMAOBMAOABCHEACHE | |
| Bromide SCHEMBL4340422 | 0.80 | F2R (0.63) | F2RMAOBMAOABCHEACHE | |
| SCHEMBL6360881 | 0.79 | F2R (0.65) | F2RMAOBMAOABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391456-B1 | 2-IMINOIMIDAZOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | EP | disclosed |
| US-7304083-B2 | 2-iminoimidazole derivatives (2) | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-12-04 | — | — | US | disclosed |