Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.59 |
| ▸ | MLYCD | O95822 | 4/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4334926 | 0.87 | MAPK14 (0.52) | MAPK14MLYCDBRD4TDO2PTGS1 | |
| SCHEMBL4332040 | 0.86 | MAPK14 (0.55) | MAPK14MLYCDBRD4TDO2PTGS1 | |
| SCHEMBL4327888 | 0.83 | MAPK14 (0.57) | MAPK14MLYCDBRD4TDO2PTGS1 | |
| SCHEMBL4527687 | 0.83 | MAPK14 (0.66) | MAPK14MLYCDBRD4TDO2PTGS1 | |
| SCHEMBL4338473 | 0.82 | MAPK14 (0.57) | MAPK14MLYCDBRD4TDO2PTGS1 | |
| SCHEMBL4341533 | 0.81 | MAPK14 (0.72) | MAPK14MLYCDBRD4TDO2PTGS1 | |
| SCHEMBL1874520 | 0.80 | MAPK14 (0.60) | MAPK14MLYCDBRD4TDO2MAPK9 | |
| SCHEMBL4346446 | 0.80 | MAPK14 (0.62) | MAPK14MLYCDBRD4TDO2MAPK9 | |
| SCHEMBL4334970 | 0.79 | MAPK14 (0.61) | MAPK14MLYCDBRD4TDO2PTGS1 | |
| SCHEMBL4336987 | 0.78 | MAPK14 (0.52) | MAPK14MLYCDBRD4TDO2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036905-B1 | PYRIDYLISOXAZOLE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2012-12-12 | — | — | EP | disclosed |
| US-8207203-B2 | Pyridylisoxazole derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-20090306145-A1 | Pyridylisoxazole Derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| EP-2036905-A1 | PYRIDYLISOXAZOLE DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306145-A1 | Pyridylisoxazole Derivatives | CNKSR1, MAPK1, MAPK3 | MAPK14 43/4885MLYCD 4475/4885BRD4 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.