Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907911 | 1.00 | HDAC8 (0.68) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL1550021 | 0.93 | HDAC8 (0.65) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL18538460 | 0.93 | HDAC8 (0.79) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL1550023 | 0.93 | HDAC8 (0.65) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL3864584 | 0.92 | HDAC8 (0.62) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL27737309 | 0.92 | HDAC8 (0.65) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL3864580 | 0.92 | HDAC8 (0.62) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL27716287 | 0.91 | HDAC8 (0.64) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL12035844 | 0.90 | HDAC8 (0.56) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 | |
| SCHEMBL15248918 | 0.89 | HDAC8 (0.60) | HDAC8MEN1HSP90AA1KMT2AAKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595952-B1 | AGONISTS OF GPR40 | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2020-11-18 | — | — | EP | disclosed |
| US-5047430-A | Glutamate Receptor Inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0339927-A2 | Amide compounds their production and use | Takeda Chemical Industries, Ltd. (JP) | 1989-11-02 | — | — | EP | disclosed |