Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329118 | 1.00 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2GSK3AGSK3B | |
| SCHEMBL13198269 | 1.00 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2GSK3AGSK3B | |
| SCHEMBL4341112 | 0.89 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2GSK3AGSK3B | |
| SCHEMBL4336504 | 0.89 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2GSK3AGSK3B | |
| SCHEMBL4327628 | 0.87 | GSK3B (0.53) | GSK3AGSK3BNTRK1PARP1DYRK1A | |
| SCHEMBL4346834 | 0.86 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2GSK3BSLC5A1 | |
| SCHEMBL4346877 | 0.86 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2GSK3BSLC5A1 | |
| SCHEMBL13198283 | 0.84 | GSK3A (0.45) | MEN1KMT2ASMN1; SMN2GSK3AGSK3B | |
| SCHEMBL4326338 | 0.84 | GSK3A (0.45) | MEN1KMT2ASMN1; SMN2GSK3AGSK3B | |
| SCHEMBL4339882 | 0.81 | GSK3B (0.48) | MEN1KMT2ASMN1; SMN2GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |
| US-7541376-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20050282880-A1 | Novel 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282880-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | MEN1 3782/4885KMT2A 2212/4885SMN1; SMN2 4812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.