Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.84 |
| ▸ | LCK | P06239 | 5/20 | 0.69 |
| ▸ | KDR | P35968 | 5/20 | 0.69 |
| ▸ | FYN | P06241 | 4/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.69 |
| ▸ | KIT | P10721 | 4/20 | 0.69 |
| ▸ | FLT1 | P17948 | 4/20 | 0.69 |
| ▸ | FLT4 | P35916 | 4/20 | 0.69 |
| ▸ | SRC | P12931 | 1/20 | 0.69 |
| ▸ | RAF1 | P04049 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4334774 | 0.92 | BRAF (0.87) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL4341656 | 0.91 | BRAF (0.86) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL4334886 | 0.91 | BRAF (1.00) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL4323654 | 0.90 | BRAF (0.92) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL4329687 | 0.90 | BRAF (0.84) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL4328372 | 0.88 | BRAF (1.00) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL4343254 | 0.88 | BRAF (1.00) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL4331344 | 0.87 | BRAF (0.85) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL15223368 | 0.86 | BRAF (0.62) | BRAFLCKKDRFYNPDGFRB | |
| SCHEMBL4331322 | 0.85 | BRAF (0.93) | BRAFLCKKDRFYNPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130224195-A1 | SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE | COSTALES ABRAN (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130224195-A1 | SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE | COSTALES ABRAN (US) | 2013-08-29 | — | — | US | disclosed |
| US-8415382-B2 | Substituted benzazoles and methods of their use as inhibitors of RAF Kinase | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2013-04-09 | — | — | US | disclosed |
| US-8415382-B2 | Substituted benzazoles and methods of their use as inhibitors of RAF Kinase | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2013-04-09 | — | — | US | disclosed |
| US-8415382-B2 | Substituted benzazoles and methods of their use as inhibitors of RAF Kinase | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2013-04-09 | — | — | US | disclosed |
| EP-1682126-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-07-01 | — | — | EP | disclosed |
| US-20090035309-A1 | Substituted Benzazoles and Methods of Their Use as Inhibitors of RAF Kinase | NOVARTIS AG | 2009-02-05 | — | — | US | disclosed |
| US-20090035309-A1 | Substituted Benzazoles and Methods of Their Use as Inhibitors of RAF Kinase | NOVARTIS AG | 2009-02-05 | — | — | US | disclosed |
| US-20090035309-A1 | Substituted Benzazoles and Methods of Their Use as Inhibitors of RAF Kinase | NOVARTIS AG | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090035309-A1 | Substituted Benzazoles and Methods of Their Use as Inhibitors of RAF Kinase | BRAF, RAF1, ARAF | BRAF 1/4885LCK 279/4885KDR 1373/4885 |
| US-20130224195-A1 | SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE | BRAF, RAF1, ARAF | BRAF 1/4885LCK 279/4885KDR 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.