SCHEMBL4337889

SCHEMBL4337889

O=C(O)CCCCCNCCOc1ccc(-c2cc3c(NCCc4ccccc4)ncnc3[nH]2)cc1

nearest known ligand 0.63

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ERBB2 P04626 12/20 0.63
KDR P35968 12/20 0.63
EGFR P00533 6/20 0.63
HDAC3 O15379 11/20 0.62
HDAC4 P56524 11/20 0.62
HDAC1 Q13547 11/20 0.62
HDAC7 Q8WUI4 11/20 0.62
HDAC2 Q92769 11/20 0.62
HDAC10 Q969S8 11/20 0.62
HDAC11 Q96DB2 11/20 0.62
HDAC8 Q9BY41 11/20 0.62
HDAC6 Q9UBN7 11/20 0.62
HDAC9 Q9UKV0 11/20 0.62
HDAC5 Q9UQL6 11/20 0.62
CSF1R P07333 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4335979 0.99 ERBB2 (0.64) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL4728921 0.93 ERBB2 (0.75) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL4335551 0.93 ERBB2 (0.75) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL4340029 0.92 ERBB2 (0.62) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL4330275 0.86 KDR (0.61) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL4332854 0.86 KDR (0.61) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL4730078 0.85 ERBB2 (0.66) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL4730490 0.85 KDR (0.82) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL14123549 0.85 ERBB2 (0.87) ERBB2KDREGFRHDAC3HDAC4
SCHEMBL4334721 0.84 EGFR (0.62) ERBB2KDREGFRHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2061772-A2 MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS Curis, Inc. (US) 2009-05-27 EP disclosed
WO-2008033747-A9 MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS CURIS INC (MA) 2008-07-24 WO disclosed
WO-2008033747-A2 MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS CURIS, INC. (US) 2008-03-20 WO disclosed