Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 7/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484711 | 0.89 | PIK3CG (0.57) | PIK3CGPIK3CDLMNAMAPTHCRTR1 | |
| SCHEMBL188733 | 0.88 | PIK3CD (0.70) | PIK3CGPIK3CDLMNAMAPTPIK3CA | |
| SCHEMBL4344893 | 0.83 | PIK3CG (0.53) | PIK3CGPIK3CDLMNAMAPTHCRTR1 | |
| SCHEMBL4344214 | 0.82 | MEN1 (0.54) | PIK3CGPIK3CDLMNAMAPTHCRTR1 | |
| SCHEMBL188457 | 0.79 | PIK3CD (0.68) | PIK3CGPIK3CDMAPTPIK3CAPIK3CB | |
| SCHEMBL4559318 | 0.79 | MAPT (0.58) | PIK3CGPIK3CDLMNAMAPTHCRTR1 | |
| SCHEMBL189293 | 0.79 | PIK3CG (0.75) | PIK3CGPIK3CDMAPTPIK3CAPIK3CB | |
| SCHEMBL189757 | 0.78 | PIK3CG (0.60) | PIK3CGPIK3CDLMNAMAPTPIK3CA | |
| SCHEMBL188330 | 0.77 | PIK3CG (0.71) | PIK3CGPIK3CDLMNAMAPTPIK3CA | |
| SCHEMBL188486 | 0.77 | PIK3CG (0.73) | PIK3CGPIK3CDLMNAMAPTPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | claimed |