Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1419497 | 0.98 | SLC1A3 (0.39) | SLC1A3SLC1A2SLC1A1BLMCA1 | |
| SCHEMBL27372501 | 0.80 | CHRM1 (0.46) | SLC1A3SLC1A2SLC1A1CHRM1AKR1A1 | |
| SCHEMBL4972136 | 0.79 | ACE2 (0.36) | BLMGABRR1CYP1A2CHRM1AKR1A1 | |
| SCHEMBL651947 | 0.77 | — | — | |
| SCHEMBL15280 | 0.77 | RNPEP (0.44) | SLC1A3SLC1A2RNPEPSLC7A5TP53 | |
| SCHEMBL10494055 | 0.77 | — | — | |
| SCHEMBL10494014 | 0.77 | — | — | |
| SCHEMBL4338848 | 0.77 | CA1 (0.45) | CA1 | |
| Propane SCHEMBL29178080 | 0.76 | CHRM1 (0.46) | SLC1A3SLC1A2SLC1A1CHRM1AKR1A1 | |
| SCHEMBL28958900 | 0.76 | CHRM1 (0.46) | SLC1A3SLC1A2SLC1A1CHRM1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2071032-A2 | The use of enzymatic resolution for the preparation of intermediates of pregabalin | Teva Pharmaceutical Industries Ltd (IL) | 2009-06-17 | — | — | EP | disclosed |
| EP-1913147-A2 | THE USE OF ENZYMATIC RESOLUTION FOR THE PREPARATION OF INTERMEDIATES OF PREGABALIN | Teva Pharmaceutical Industries Ltd (IL) | 2008-04-23 | — | — | EP | disclosed |
| US-20080026433-A1 | Use of enzymatic resolution for the preparation of intermediates of pregabalin | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-01-31 | — | — | US | disclosed |
| WO-2007143113-A2 | THE USE OF ENZYMATIC RESOLUTION FOR THE PREPARATION OF INTERMEDIATES OF PREGABALIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-12-13 | — | — | WO | disclosed |