Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 10/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CCR5 | P51681 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 6/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652012 | 1.00 | CCR1 (0.81) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL652013 | 1.00 | CCR1 (0.81) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL4341062 | 1.00 | CCR1 (0.81) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL18776061 | 0.92 | CCR1 (0.81) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL18895909 | 0.91 | CCR1 (0.80) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL10287870 | 0.90 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL438487 | 0.90 | CCR1 (1.00) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL2197331 | 0.90 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL656424 | 0.90 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL438265 | 0.90 | CCR1 (1.00) | CCR1CHRM2CCR5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448566-B3 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARM INC (US) | 2009-04-08 | — | — | EP | disclosed |
| EP-1448566-B1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARM INC (US) | 2006-03-15 | — | — | EP | disclosed |