Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342235 | 0.91 | GRIK1 (0.51) | MEN1MAPTKMT2ARAB9AGRIK1 | |
| SCHEMBL4358279 | 0.80 | MEN1 (0.63) | MEN1MAPTKMT2ARAB9ANPSR1 | |
| SCHEMBL23831565 | 0.77 | TRPV1 (0.62) | MEN1MAPTKMT2ARAB9ANPSR1 | |
| SCHEMBL23831812 | 0.75 | TRPV1 (0.63) | MEN1MAPTKMT2ARAB9AGRIK1 | |
| SCHEMBL30792273 | 0.75 | TRPV1 (0.63) | MEN1MAPTKMT2ARAB9AGRIK1 | |
| SCHEMBL30105034 | 0.75 | MEN1 (0.62) | MEN1MAPTKMT2ARAB9AGRIK1 | |
| SCHEMBL23831843 | 0.75 | MEN1 (0.62) | MEN1MAPTKMT2ARAB9AGRIK1 | |
| SCHEMBL23831629 | 0.74 | MEN1 (0.50) | MEN1MAPTKMT2ARAB9ANPSR1 | |
| SCHEMBL30105032 | 0.74 | MEN1 (0.50) | MEN1MAPTKMT2ARAB9ANPSR1 | |
| SCHEMBL4342004 | 0.74 | KMT2A (0.54) | MEN1MAPTKMT2ARAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |