Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 9/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.52 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342810 | 1.00 | KCNA5 (0.52) | KCNA5KCNH2SQORDPP4ABCC8 | |
| SCHEMBL2168453 | 0.84 | KCNA5 (0.58) | KCNA5KCNH2SQORDPP4ABCC8 | |
| SCHEMBL2169804 | 0.83 | KCNA5 (0.59) | KCNA5KCNH2SQORDPP4ABCC8 | |
| SCHEMBL2169294 | 0.83 | KCNA5 (0.59) | KCNA5KCNH2SQORDPP4ABCC8 | |
| SCHEMBL2169298 | 0.83 | KCNA5 (0.59) | KCNA5KCNH2SQORDPP4ABCC8 | |
| SCHEMBL2169067 | 0.82 | KCNA5 (0.50) | KCNA5KCNH2SQORDPP4ABCC8 | |
| SCHEMBL2168279 | 0.78 | KDM4E (0.49) | KCNA5KCNH2SQORABCC8KCNJ11 | |
| SCHEMBL5510744 | 0.76 | KCNA5 (0.55) | KCNA5KCNH2SQORDPP4ADORA1 | |
| SCHEMBL2640082 | 0.75 | KCNA5 (0.74) | KCNA5KCNH2KDM4EMAPTALDH1A1 | |
| SCHEMBL2168475 | 0.73 | KCNA5 (0.45) | KCNA5KCNH2SQORDPP4ABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667683-A4 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-04-29 | — | — | EP | disclosed |
| EP-1667683-A2 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030129-A2 | QUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |