Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413122 | 0.79 | HPGD (0.50) | PARP1HPGDTDP1HDAC8HDAC6 | |
| SCHEMBL436125 | 0.78 | TSHR (0.41) | HPGDTDP1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL1210113 | 0.78 | CTNNB1 (0.58) | PARP1CTNNB1WNT3AHPGDTDP1 | |
| SCHEMBL31309786 | 0.78 | CTNNB1 (0.58) | PARP1CTNNB1WNT3AHPGDTDP1 | |
| SCHEMBL31309803 | 0.77 | PARP1 (0.44) | PARP1CTNNB1WNT3AHPGDTDP1 | |
| SCHEMBL24776935 | 0.77 | PARP1 (0.52) | PARP1HPGDTDP1HDAC8HDAC6 | |
| SCHEMBL22341510 | 0.76 | HDAC8 (0.52) | PARP1CTNNB1WNT3AHDAC8HDAC6 | |
| SCHEMBL28874159 | 0.74 | CTNNB1 (0.54) | PARP1CTNNB1WNT3AHPGDTDP1 | |
| SCHEMBL21287986 | 0.74 | F10 (0.45) | HDAC8RAB9ANPC1 | |
| SCHEMBL10040531 | 0.73 | TDP1 (0.49) | PARP1CTNNB1WNT3AHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595952-A1 | AGONISTS OF GPR40 | Connexios Life Sciences Pvt. Ltd. (IN) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012011125-A1 | AGONISTS OF GPR40 | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |