Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.54 |
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.44 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565351 | 0.95 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL3689501 | 0.91 | PIK3CG (0.53) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL4454726 | 0.86 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL4338556 | 0.86 | PIK3CG (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL3691116 | 0.83 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL3803465 | 0.83 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL189153 | 0.82 | PIK3CG (0.69) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL4343994 | 0.82 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL4346342 | 0.82 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL4540221 | 0.81 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | claimed |
| WO-2012065057-A2 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |