Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | ACR | P10323 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982620 | 0.88 | ESR1 (0.42) | L3MBTL1SMN1; SMN2TP53NPC1MEN1 | |
| SCHEMBL341880 | 0.84 | KMT2A (0.53) | L3MBTL1SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL2989104 | 0.84 | AKR1C3 (0.53) | RAB9ANPC1KMT2APOLBMRGPRX4 | |
| SCHEMBL6625609 | 0.84 | KDM4E (0.44) | L3MBTL1ALDH1A1TSHRPOLBLMNA | |
| SCHEMBL18304558 | 0.84 | KDM4E (0.44) | L3MBTL1ALDH1A1TSHRPOLBLMNA | |
| SCHEMBL8680473 | 0.84 | CA1 (0.52) | MAPTHTT | |
| SCHEMBL2981524 | 0.83 | HSP90AA1 (0.43) | L3MBTL1RAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL25984931 | 0.83 | PARP1 (0.58) | CES2CES1 | |
| SCHEMBL8324608 | 0.82 | CYSLTR1 (0.49) | L3MBTL1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL21280074 | 0.82 | HSP90AA1 (0.42) | TP53RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416256-A1 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE | JANSSEN PHARAMCEUTICA NV (BE) | 2023-12-28 | — | — | US | disclosed |
| WO-2013083991-A1 | NOVEL COMPOUNDS AND THEIR USE IN THERAPY | IMPERIAL INNOVATIONS LIMITED (GB) | 2013-06-13 | — | — | WO | disclosed |
| EP-1112274-B1 | CHEMILUMINESCENT 1,2-DIOXETANES | GIRI BRIJ P (US) | 2009-12-09 | — | — | EP | disclosed |
| EP-2048140-A1 | Deuterated chemiluminescent 1,2-dioxetanes | Giri, Brij P. (US) | 2009-04-15 | — | — | EP | disclosed |
| US-7422908-B2 | Chemiluminescent 1,2-dioxetanes | GIRI BRIJ P | 2008-09-09 | — | — | US | disclosed |
| US-7422908-B2 | Chemiluminescent 1,2-dioxetanes | GIRI BRIJ P | 2008-09-09 | — | — | US | disclosed |
| US-7416898-B2 | Chemiluminescent 1,2-dioxetanes | GIRI BRIJ P | 2008-08-26 | — | — | US | disclosed |
| US-7416898-B2 | Chemiluminescent 1,2-dioxetanes | GIRI BRIJ P | 2008-08-26 | — | — | US | disclosed |
| EP-1453822-A4 | DEUTERIUM-BASED CHEMILUMINESCENT 1,2-DIOXETANES | GIRI BRIJ P (US) | 2004-11-24 | — | — | EP | disclosed |
| EP-1453822-A2 | DEUTERIUM-BASED CHEMILUMINESCENT 1,2-DIOXETANES | Giri, Brij P. (US) | 2004-09-08 | — | — | EP | disclosed |
| US-5386017-A | Can be converted to stable aryl substituted 1,2-dioxetanes which decompose when activated to produce light and carbonyl compounds | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0254051-B1 | Chemiluminescent 1,2-dioxetane compounds | UNIV WAYNE STATE (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0595369-A1 | Alkene compounds | TROPIX, INC. (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0458965-A4 | PROCESS FOR THE PREPARATION OF VINYL ETHERS | — | 1993-07-28 | — | — | EP | disclosed |
| EP-0458965-A1 | PROCESS FOR THE PREPARATION OF VINYL ETHERS. | UNIV WAYNE STATE (US) | 1991-12-04 | — | — | EP | disclosed |
| WO-1991009002-A1 | PROCESS FOR THE PREPARATION OF VINYL ETHERS | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1991-06-27 | — | — | WO | disclosed |
| US-4983779-A | Process for the preparation of vinyl ethers | THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1991-01-08 | — | — | US | disclosed |
| US-4962192-A | Chemiluminescent 1,2-dioxetane compounds | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1990-10-09 | — | — | US | disclosed |
| US-4857652-A | Chemiluminescent 1,2-dioxetane compounds | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0254051-A2 | Chemiluminescent 1,2-dioxetane compounds | THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1988-01-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416256-A1 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE | NFKBIA, IKBKB, NFRKB | L3MBTL1 2176/4885SMN1; SMN2 4654/4885TP53 584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.