Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | CDC25A | P30304 | 1/20 | 0.53 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.53 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188910 | 0.87 | PIK3CD (0.76) | PIK3CDMAPTPOLBPIK3CGPIK3CA | |
| SCHEMBL188712 | 0.85 | PIK3CD (0.74) | PIK3CDMAPTPIK3CGPIK3CAPIK3CB | |
| SCHEMBL188337 | 0.84 | MEN1 (0.66) | PIK3CDMAPTPOLBPIK3CGPIK3CA | |
| SCHEMBL188870 | 0.83 | PIK3CD (0.68) | PIK3CDMAPTPIK3CGPIK3CAPIK3CB | |
| SCHEMBL189291 | 0.82 | PIK3CD (0.62) | PIK3CDMAPTPOLBPIK3CGPIK3CA | |
| SCHEMBL188662 | 0.82 | PIK3CG (0.71) | PIK3CDMAPTPOLBPIK3CGPIK3CA | |
| SCHEMBL12373069 | 0.81 | PIK3CD (0.66) | PIK3CDMAPTPIK3CGPIK3CAPIK3CB | |
| SCHEMBL189862 | 0.81 | MAPT (0.69) | PIK3CDMAPTPOLBPIK3CGPIK3CA | |
| Hydrochloric Acid SCHEMBL14861065 | 0.81 | PIK3CG (0.70) | PIK3CDMAPTPOLBPIK3CGPIK3CA | |
| SCHEMBL189007 | 0.80 | PIK3CG (0.74) | PIK3CDMAPTPIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |