Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.59 |
| ▸ | PDE1A | P54750 | 8/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | PDE6A | P16499 | 2/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE6D | O43924 | 1/20 | 0.48 |
| ▸ | PDE9A | O76083 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | PDE6G | P18545 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PDE6B | P35913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338924 | 0.83 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL8218943 | 0.81 | PDE5A (0.70) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL8257008 | 0.80 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL12822873 | 0.79 | PDE5A (0.67) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL974189 | 0.79 | PDE5A (0.61) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL6793077 | 0.79 | PDE5A (0.61) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL974600 | 0.79 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL973032 | 0.78 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL18184293 | 0.78 | PDE5A (0.70) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL12823651 | 0.78 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009013286-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | claimed |