Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.52 |
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | AKT2 | P31751 | 3/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.41 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348275 | 1.00 | GSK3B (0.52) | GSK3BAKT1AKT2AKT3KMT2A | |
| Hydrochloric Acid SCHEMBL4348323 | 0.99 | GSK3B (0.51) | GSK3BAKT1AKT2AKT3KMT2A | |
| Hydrochloric Acid SCHEMBL4348331 | 0.99 | GSK3B (0.51) | GSK3BAKT1AKT2AKT3KMT2A | |
| Hydrochloric Acid SCHEMBL4355615 | 0.93 | GSK3B (0.50) | GSK3BAKT1AKT2AKT3KMT2A | |
| Hydrochloric Acid SCHEMBL4356201 | 0.93 | GSK3B (0.50) | GSK3BAKT1AKT2AKT3KMT2A | |
| Hydrochloric Acid SCHEMBL4348361 | 0.92 | GSK3B (0.44) | GSK3BAKT1AKT2AKT3KMT2A | |
| Hydrochloric Acid SCHEMBL4348372 | 0.92 | GSK3B (0.44) | GSK3BAKT1AKT2AKT3KMT2A | |
| Hydrochloric Acid SCHEMBL4349039 | 0.91 | GSK3B (0.45) | GSK3BKMT2AAURKAAURKBHDAC1 | |
| Hydrochloric Acid SCHEMBL4349045 | 0.91 | GSK3B (0.45) | GSK3BKMT2AAURKAAURKBHDAC1 | |
| Hydrochloric Acid SCHEMBL4343985 | 0.91 | GSK3B (0.49) | GSK3BAKT1AKT2AKT3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |