Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348573 | 1.00 | HDAC3 (0.49) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL4346709 | 0.93 | MAP3K7 (0.48) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL4346713 | 0.93 | MAP3K7 (0.48) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL4343847 | 0.90 | GSK3B (0.51) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL4343841 | 0.90 | GSK3B (0.51) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL4343758 | 0.89 | NAMPT (0.50) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL5260705 | 0.83 | KMT2A (0.46) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL5262252 | 0.83 | KMT2A (0.46) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL5259595 | 0.81 | KMT2A (0.44) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL5259592 | 0.81 | KMT2A (0.44) | HDAC3HDAC1HDAC8HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |