Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | MAP2 | P11137 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344042 | 0.90 | BRD4 (0.38) | BRD4CHEK1 | |
| SCHEMBL2199409 | 0.81 | IKBKB (0.52) | BRD4IKBKBCAMKK2CHUKINSR | |
| SCHEMBL13685462 | 0.81 | BRD4 (0.47) | BRD4IKBKBCAMKK2CHUKINSR | |
| SCHEMBL2199300 | 0.79 | IKBKB (0.50) | BRD4IKBKBCAMKK2CHUKINSR | |
| SCHEMBL2198614 | 0.78 | IKBKB (0.47) | BRD4IKBKBCHEK1 | |
| SCHEMBL2196927 | 0.77 | CDC7 (0.54) | BRD4IKBKBCAMKK2CHUKINSR | |
| SCHEMBL2199890 | 0.77 | BRD4 (0.42) | BRD4IKBKBCAMKK2CHUKINSR | |
| SCHEMBL2201526 | 0.77 | BRD4 (0.45) | BRD4IKBKBCAMKK2CHUKINSR | |
| SCHEMBL2197555 | 0.77 | BRD4 (0.49) | BRD4CAMKK2CHUKINSRMAPK8 | |
| SCHEMBL2201344 | 0.76 | HTT (0.57) | BRD4IKBKBCAMKK2CHUKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116530-A1 | NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-11 | — | — | EP | claimed |