Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 12/20 | 0.48 |
| ▸ | CNR2 | P34972 | 10/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348429 | 0.89 | CNR1 (0.48) | CNR1CNR2MEN1KMT2AKDM4E | |
| SCHEMBL4348577 | 0.85 | KMT2A (0.47) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL4354540 | 0.82 | KDM4E (0.49) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL4348246 | 0.82 | ABL1 (0.48) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL13614198 | 0.80 | MAPT (0.53) | CNR1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL4348111 | 0.80 | KDM4E (0.50) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL4352546 | 0.80 | CLK1 (0.44) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL4344646 | 0.79 | PDE5A (0.50) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL4348258 | 0.79 | MEN1 (0.47) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL12035332 | 0.77 | TTK (0.48) | MEN1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110312992-A1 | Inhibitors of C-Kit and Uses Thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-12-22 | — | — | US | claimed |
| US-20120302565-A1 | KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF | M.D. ANDERSON CANCER CENTER (US) | 2012-11-29 | — | — | US | disclosed |
| US-8268809-B2 | Kinase inhibitors for preventing or treating pathogen infection and method of use thereof | EMORY UNIVERSITY (US) | 2012-09-18 | — | — | US | disclosed |
| US-20110312992-A1 | Inhibitors of C-Kit and Uses Thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-12-22 | — | — | US | disclosed |
| US-20110312992-A1 | Inhibitors of C-Kit and Uses Thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-12-22 | — | — | US | disclosed |
| US-20100249122-A1 | Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof | EMORY UNIVERSITY (US) | 2010-09-30 | — | — | US | disclosed |
| US-20090281115-A1 | INHIBITORS OF C-KIT AND USES THEREOF | Board of Regents, The University of Texas System, a Texas University (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090281115-A1 | INHIBITORS OF C-KIT AND USES THEREOF | Board of Regents, The University of Texas System, a Texas University (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2008005877-A2 | INHIBITORS OF C-KIT AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249122-A1 | Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof | MAP3K1, MAP3K2, MAP3K6 | CNR1 3733/4885CNR2 4068/4885MEN1 4195/4885 |
| US-20110312992-A1 | Inhibitors of C-Kit and Uses Thereof | KIT, CHUK, MASTL | CNR1 4064/4885CNR2 4132/4885MEN1 1273/4885 |
| US-20120302565-A1 | KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF | MAP3K1, MAP3K2, MAP3K6 | CNR1 3733/4885CNR2 4068/4885MEN1 4195/4885 |
| US-20090281115-A1 | INHIBITORS OF C-KIT AND USES THEREOF | KIT, CHUK, MASTL | CNR1 4064/4885CNR2 4132/4885MEN1 1273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.